Industrial Internet of Things, Industry 4.0 and smart manufacturing concepts are familiar to architects of industrial automation and controls. How are programmable logic controllers (PLCs) and industrial PCs (IPCs), embedded controllers, programmable automation controllers (PACs), smart input/output (I/O) modules, other logic devices and related software helping IIoT promises envisioned? If an application needs a controller, what kind should be considered and why? Does IIoT imply cybersecurity and interoperability or are those separate considerations? What about scalability and growth versus a “set it and forget it” design? Are you asking the right questions? Will you have the right answers when someone else asks?